Interdisciplinary PhD in Structural and Computational Biology and Quantitative Biosciences

Merrins Wins Partnership Grant to Address Diabetes

Photo of Matthew Merrins
Professor Matthew Merrins

The Wisconsin Partnership Program at the UW School of Medicine at Public Health has awarded $300,000 through its New Investigator Program.

The awards, each $100,000 over two years, support early-career investigators who are taking innovative approaches to address a diverse range of public health issues in Wisconsin.

Biomolecular chemistry professor Matthew Merrins won one of the awards for his project titled “Reprogramming β-cell Metabolism to Prevent and Rescue Type 2 Diabetes.”

The prevalence of type 2 diabetes in Wisconsin is rapidly climbing, imposing a significant burden on the health care system. The clinical manifestation of diabetes is attributed to the failure of insulin secretion from pancreatic β (beta) cells.

This project proposes that activating a metabolic enzyme, pyruvate kinase, has the potential to prevent diabetes and rescue insulin secretion from the diabetic β-cell. The studies are needed to provide a firm scientific basis for a clinical intervention that preserves β-cell metabolic health in people.

To read more about this grant, see the link below.