Interdisciplinary PhD in Structural and Computational Biology and Quantitative Biosciences


Trainers in the Biophysics program have homes in thirteen different Departments belonging to four different Colleges: Bacteriology and Biochemistry (Agricultural & Life Sciences); Chemical & Biological Engineering, Biomedical Engineering, and Engineering Physics (Engineering); Chemistry, Integrative Biology, and Physics (Letters & Science); Biomolecular Chemistry, Cell and Regenerative Biology, Medicine, Neuroscience, and Oncology (Medicine & Public Health).

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Paul G. Ahlquist

Molecular mechanisms of virus replication and host interactions

Thomas Brunold

Spectroscopic methods applied to metalloenzyme structure and function

Andrew R. Buller

Protein engineering and biocatalysis

Mark E. Burkard

How protein kinases regulate human cell division and applying gained knowledge to improve treatment of breast cancer

Judith Burstyn

Bioinorganic chemistry, gas-sensing metalloproteins

Briana M. Burton

DNA transport across membranes

Samuel E. Butcher

Structural biology of RNA interactions that regulate gene expression

Silvia Cavagnero

Protein structure, folding, dynamics and aggregation in the cell; role of ribosome and molecular chaperones

Edwin Chapman

Molecular mechanisms that underlie neuronal exocytosis

Joshua J. Coon

Bioanalytical chemistry, mass spectrometry and proteomics

Scott M. Coyle

Understanding and engineering microscale molecular and cellular machines

Cynthia M. Czajkowski

Structure/function relationship in neurotransmitter receptors

Katrina T. Forest

Structures, functions and mechanisms of microbial proteins; using crystallography, protein engineering, biochemistry, chemical biology and classic microbiology

Brian G. Fox

Biochemical, catalytic, and spectroscopic studies of redox active enzymes; protein engineering

Ying Ge

Cardiovascular Systems Biology

Samuel H. Gellman

Proteins and protein-like molecules: design, synthesis, structure and function

Pupa Gilbert

Biophotonics; gadolinium neutron capture therapy

Randall H. Goldsmith

Single-molecule methods to study chemical reactions, biophysical processes, and materials properties

Timothy Grant

Studying the structure and dynamics of biological macromolecules using cryo-EM

Aviad Hai

Bioelectronic sensors for non-destructive electrophysiology

Jeffrey D. Hardin

Epithelial migration and embryonic development

Katherine Henzler-Wildman

Dynamics and function of integral membrane proteins, secondary active transport, ion channels

Hazel M. Holden

Structure and function of enzymes

Aaron A. Hoskins

Mechanistic studies of eukaryotic RNA processing using chemical, genetic, and biophysical approaches

Xuhui Huang

Elucidating the dynamics of these conformational changes

Meyer B. Jackson

Biophysical studies of neuronal signaling

Mathew V. Jones

Mechanisms of inhibitory synaptic transmission

Betul Kacar

Investigating molecular mechanisms of evolution and the origins of life

James L. Keck

Structural mechanisms of genome maintenance

Robert N. Kirchdoerfer

Structural and biochemical exploration of RNA virus entry and replication

Robert Landick

RNA polymerase structure/function; regulation of transcript elongation in bacteria and humans

Lingjun Li

Drug Action and Drug Discovery

Ci Ji Lim

Mechanism of telomere maintenance; Structure-function studies of biological machines by cryo-EM and single-molecule imaging

Megan McClean

Systems biology, synthetic biology, cellular engineering, signal processing

Matthew J. Merrins

Enzymatic regulation of nutrient metabolism and hormone secretion in pancreatic islets

Jacob Notbohm

How biological cells adhere, push, pull, and move, using mechanics, soft matter physics, applied math, and cell biology

Srivatsan Raman

Protein allostery, orthogonal transcriptional systems, programmable synthetic bacteriophages

Ivan Rayment

Molecular basis of protein function

M. Thomas Record, Jr.

Biophysical chemistry of proteins, nucleic acids and their interactions

Chad M. Rienstra

Development and application of solid-state NMR spectroscopy to protein, lipid and small molecule structure and dynamics

Gail A. Robertson

Molecular mechanisms of ion channel function

Philip A. Romero

Protein engineering, computational biology, high-throughput technology

Krishanu Saha

Stem cell biology, genome engineering and biomaterials expertise to ask unique questions about human biology and disease

David Schwartz

Single molecule approaches to whole genome analysis

Alessandro Senes

Biochemical and computational studies of membrane protein interactions

Nathan M. Sherer

Cell biology of viral HIV-1 replication; single cell imaging technologies and biochemical and cell-based assays

Raunak Sinha

Visual processing in the retina: How cellular, synaptic and circuit mechanisms shape retinal structure and function

Melissa Skala

Combating cancer using photonics-based technologies and developing personal cancer treatment strategies

Lloyd M. Smith

Development and application of novel bioanalytical tools

Aussie Suzuki

Cell biology, machanobiology, cancer biology, nanobiology, and biophysics in cell division machinery

Reid C. Van Lehn

Biomolecular simulation; nano-bio interactions; complex bio interfaces; cotranslational protein synthesis; biomembranes

Ophelia S. Venturelli

Understanding and engineering microbial communities across space and time

Amy M. Weeks

Spatially-resolved mapping of post-translational modifications; protein engineering; chemoproteomics

Elizabeth R. Wright

3D structure of viruses, bacteria, and mammalian cells by cryo-electron microscopy

Yongna Xing

Structural biology of cancer

John Yin

Theoretical and experimental approaches to understand how viruses grow and evolve

Martin Zanni

We develop and utilize ultrafast multidimensional spectroscopies to study topics in biophysics and materials science

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