Interdisciplinary PhD in Structural and Computational Biology and Quantitative Biosciences


Trainers in the Biophysics program have homes in fifteen different Departments belonging to five different Colleges: Bacteriology and Biochemistry (Agricultural & Life Sciences); Chemical & Biological Engineering, Biomedical Engineering, and Engineering Physics (Engineering); Botany, Chemistry, Integrative Biology, and Physics (Letters & Science); Biomolecular Chemistry, Cell and Regenerative Biology, Medicine, Neuroscience, and Oncology (Medicine & Public Health); and Pharmaceutical Sciences (School of Pharmacy).

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Paul G. Ahlquist

Dept. of Oncology & Institute for Molecular Virology

Molecular mechanisms of virus replication and host interactions

David Baum

Department of Botany

Plant phylogenetics; conceptual issues in evolution and systematics; origin of life

Thomas Brunold

Department of Chemistry

Spectroscopic methods applied to metalloenzyme structure and function

Andrew R. Buller

Department of Chemistry

Protein engineering and biocatalysis

Mark E. Burkard

Department of Medicine

How protein kinases regulate human cell division and applying gained knowledge to improve treatment of breast cancer

Judith Burstyn

Department of Chemistry

Bioinorganic chemistry, gas-sensing metalloproteins

Briana M. Burton

Department of Bacteriology

DNA transport across membranes

Samuel E. Butcher

Department of Biochemistry

Structural biology of RNA interactions that regulate gene expression

Silvia Cavagnero

Department of Chemistry

Protein structure, folding, dynamics and aggregation in the cell; role of ribosome and molecular chaperones

Edwin Chapman

Dept. of Neuroscience & Howard Hughes Medical Institute

Molecular mechanisms that underlie neuronal exocytosis

Joshua J. Coon

Department of Chemistry

Bioanalytical chemistry, mass spectrometry and proteomics

Scott M. Coyle

Department of Biochemistry

Understanding and engineering microscale molecular and cellular machines

Cynthia M. Czajkowski

Department of Neuroscience

Structure/function relationship in neurotransmitter receptors

Katrina T. Forest

Department of Bacteriology

Structures, functions and mechanisms of microbial proteins; using crystallography, protein engineering, biochemistry, chemical biology and classic microbiology

Ying Ge

Dept. of Cell and Regenerative Biology

Cardiovascular Systems Biology

Samuel H. Gellman

Department of Chemistry

Proteins and protein-like molecules: design, synthesis, structure and function

Pupa Gilbert

Biophotonics; gadolinium neutron capture therapy

Randall H. Goldsmith

Single-molecule methods to study chemical reactions, biophysical processes, and materials properties

Timothy Grant

Studying the structure and dynamics of biological macromolecules using cryo-EM

Aviad Hai

Department of Biomedical Engineering

Bioelectronic sensors for non-destructive electrophysiology

Jeffrey D. Hardin

Epithelial migration and embryonic development

Katherine Henzler-Wildman

Dynamics and function of integral membrane proteins, secondary active transport, ion channels

Hazel M. Holden

Structure and function of enzymes

Aaron A. Hoskins

Department of Biochemistry

Mechanistic studies of eukaryotic RNA processing using chemical, genetic, and biophysical approaches

Xuhui Huang

Department of Chemistry

Elucidating the dynamics of these conformational changes

Meyer B. Jackson

Department of Neuroscience

Biophysical studies of neuronal signaling

Jiaoyang Jiang

Structure, mechanism and function of protein glycosylation in biology and disease

Mathew V. Jones

Department of Neuroscience

Mechanisms of inhibitory synaptic transmission

Betul Kacar

Department of Bacteriology

Investigating molecular mechanisms of evolution and the origins of life

James L. Keck

Structural mechanisms of genome maintenance

Robert N. Kirchdoerfer

Structural and biochemical exploration of RNA virus entry and replication

Robert Landick

RNA polymerase structure/function; regulation of transcript elongation in bacteria and humans

Lingjun Li

Department of Pharmaceutical Sciences

Drug Action and Drug Discovery

Ci Ji Lim

Department of Biochemistry

Mechanism of telomere maintenance; Structure-function studies of biological machines by cryo-EM and single-molecule imaging

Megan McClean

Systems biology, synthetic biology, cellular engineering, signal processing

Matthew J. Merrins

Enzymatic regulation of nutrient metabolism and hormone secretion in pancreatic islets

Jacob Notbohm

How biological cells adhere, push, pull, and move, using mechanics, soft matter physics, applied math, and cell biology

Srivatsan Raman

Departments of Biochemistry

Protein allostery, orthogonal transcriptional systems, programmable synthetic bacteriophages

Ivan Rayment

Molecular basis of protein function

M. Thomas Record, Jr.

Biophysical chemistry of proteins, nucleic acids and their interactions

Chad M. Rienstra

Development and application of solid-state NMR spectroscopy to protein, lipid and small molecule structure and dynamics

Gail A. Robertson

Department of Neuroscience

Molecular mechanisms of ion channel function

Philip A. Romero

Protein engineering, computational biology, high-throughput technology

Krishanu Saha

Department of Biomedical Engineering

Stem cell biology, genome engineering and biomaterials expertise to ask unique questions about human biology and disease

David Schwartz

Department of Chemistry

Single molecule approaches to whole genome analysis

Alessandro Senes

Biochemical and computational studies of membrane protein interactions

Nathan M. Sherer

Dept. of Oncology & Institute for Molecular Virology

Cell biology of viral HIV-1 replication; single cell imaging technologies and biochemical and cell-based assays

Raunak Sinha

Visual processing in the retina: How cellular, synaptic and circuit mechanisms shape retinal structure and function

Melissa Skala

Department of Biomedical Engineering

Combating cancer using photonics-based technologies and developing personal cancer treatment strategies

Lloyd M. Smith

Development and application of novel bioanalytical tools

Aussie Suzuki

Cell biology, machanobiology, cancer biology, nanobiology, and biophysics in cell division machinery

Reid C. Van Lehn

Biomolecular simulation; nano-bio interactions; complex bio interfaces; cotranslational protein synthesis; biomembranes

Ophelia S. Venturelli

Depts. of Biochemistry, Bacteriology & Chemical and Biological Engineering

Understanding and engineering microbial communities across space and time

Amy M. Weeks

Spatially-resolved mapping of post-translational modifications; protein engineering; chemoproteomics

Elizabeth R. Wright

Dept. of Biochemistry & Morgridge Institute for Research

3D structure of viruses, bacteria, and mammalian cells by cryo-electron microscopy

Yongna Xing

Department of Oncology

Structural biology of cancer

John Yin

Dept. of Chemical & Biological Engineering

Theoretical and experimental approaches to understand how viruses grow and evolve

Martin Zanni

Department of Chemistry

We develop and utilize ultrafast multidimensional spectroscopies to study topics in biophysics and materials science

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