Labs

Molecular mechanisms of virus replication and host interactions

Defining Mechanisms of Diet-Host-Microbiota-Immune Interactions

Regulation of membrane transport during development and disease

Microphysiological systems

Plant phylogenetics; conceptual issues in evolution and systematics; origin of life

Investigating cellular scale phenomena from both a physical and biological sciences perspective

Self-organization in cell division and cell repair

Measuring and programming cellular mechanobiology

Spectroscopic methods applied to metalloenzyme structure and function

Protein engineering and biocatalysis

DNA transport across membranes

Structural biology of RNA interactions that regulate gene expression

Protein structure, folding, dynamics and aggregation in the cell; role of ribosome and molecular chaperones

Molecular mechanisms that underlie neuronal exocytosis

Interactions of the gut microbiome with the host; intestinal metabolism in health and disease

Bioanalytical chemistry, mass spectrometry and proteomics

Understanding and engineering microscale molecular and cellular machines

Brainstem Circuits for Motor Control

Structure/function relationship in neurotransmitter receptors

Structures, functions and mechanisms of microbial proteins; using crystallography, protein engineering, biochemistry, chemical biology and classic microbiology

Proteins and protein-like molecules: design, synthesis, structure and function

Biophotonics; gadolinium neutron capture therapy

Molecular basis of bioenergetic systems involved in photosynthesis

Single-molecule methods to study chemical reactions, biophysical processes, and materials properties

Studying the structure and dynamics of biological macromolecules using cryo-EM

Bioelectronic sensors for non-destructive electrophysiology

Epithelial migration and embryonic development

Dynamics and function of integral membrane proteins, secondary active transport, ion channels

Mechanisms regulating retinal circuit organization and maintenance

Mechanistic studies of eukaryotic RNA processing using chemical, genetic, and biophysical approaches

Neural basis of vision and visually guided behavior

Unraveling Protein Dynamics with Molecular Simulations and Machine Learning Tools

Biophysical studies of neuronal signaling

Structure, mechanism and function of protein glycosylation in biology and disease

Investigating molecular mechanisms of evolution and the origins of life

Structural mechanisms of genome maintenance

Structural and biochemical exploration of RNA virus entry and replication

RNA polymerase structure/function; regulation of transcript elongation in bacteria and humans

Drug Action and Drug Discovery

Mechanism of telomere maintenance; Structure-function studies of biological machines by cryo-EM and single-molecule imaging

Systems biology, synthetic biology, cellular engineering, signal processing

How do leading and lagging strand stress responses and mutagenic bias differ?

Enzymatic regulation of nutrient metabolism and hormone secretion in pancreatic islets

Discovery, characterization, and evolution of enzymes for biocatalysis and chemical biology

How biological cells adhere, push, pull, and move, using mechanics, soft matter physics, applied math, and cell biology

Function and regulation of RNA condensates in development

Protein allostery, orthogonal transcriptional systems, programmable synthetic bacteriophages

Development and application of solid-state NMR spectroscopy to protein, lipid and small molecule structure and dynamics

Genomic Organization and Transcriptional Regulation

Molecular mechanisms of ion channel function

Stem cell biology, genome engineering and biomaterials expertise to ask unique questions about human biology and disease

Biochemical and computational studies of membrane protein interactions

Cell biology of viral HIV-1 replication; single cell imaging technologies and biochemical and cell-based assays

Visual processing in the retina: How cellular, synaptic and circuit mechanisms shape retinal structure and function

Combating cancer using photonics-based technologies and developing personal cancer treatment strategies

Development and application of novel bioanalytical tools

Cell biology, machanobiology, cancer biology, nanobiology, and biophysics in cell division machinery

Biomolecular simulation; nano-bio interactions; complex bio interfaces; cotranslational protein synthesis; biomembranes

Bacterial Stress Response, Nucleotide Signaling, Mutagenesis, Antibiotic Resistance

Predicting biomolecular dynamics; understanding roles of dynamics in function, evolution, design

Spatially-resolved mapping of post-translational modifications; protein engineering; chemoproteomics

3D structure of viruses, bacteria, and mammalian cells by cryo-electron microscopy

Structural biology of cancer

Protein-Protein Interactions At The Host-Pathogen Interface

Developing new bioanalytical methods using nanophotonic tools

Theoretical and experimental approaches to understand how viruses grow and evolve

We develop and utilize ultrafast multidimensional spectroscopies to study topics in biophysics and materials science

Demystifying Mechanotransduction in Brain Development and Disorders