Jon Audhya

Regulation of membrane transport during development and disease

Our laboratory is committed to understanding the fundamental mechanisms by which membrane proteins, lipids, and other macromolecules are transported throughout eukaryotic cells. To do so, we take advantage of numerous interdisciplinary approaches, including single molecule imaging, biophysics, biochemistry, molecular biology and high-resolution fluorescence and electron microscopy.
Additionally, we use a variety of experimental systems, ranging from CRISPR-edited cell lines expressing fluorescently tagged genes of interest, to human induced pluripotent stem cells (iPSCs), and Sprague Dawley rats harboring mutations associated with disease. Although basic research is the cornerstone of our program, we also aim to define pathomechanisms that underlie human disease, with a focus on the relationship between mutations in key trafficking components and neurodegeneration.