Aarushi Bhargava
Credentials: Department Biomedical Engineering
Position title: Assistant Professor
Email: aarushi.bhargava@wisc.edu
Address:
2160, Engineering, Centers Building
1550 Engineering Drive
- Lab Website
- Lab Website
- Education
- Humboldt Postdoctoral Fellow, Max Planck Institute for Intelligent Systems, Stuttgart, Germany – Postdoctoral Scholar, University of Chicago, US – PhD, Biomedical Engineering and Mechanics, Virginia Tech, US – MSc., Biological Sciences, Birla Institute of Science and Technology, Pilani, India – B.E. (Hons.) Mechanical Engineering, Birla Institute of Science and Technology, Pilani, India
- Research Areas
- Biotechnology, Personalized Medicine, Structural biology
Sonic (Acoustic) interaction mechanics with soft materials
Our group focuses on understanding the mechanics of ultrasound interaction with soft materials (synthetic and biological) at microscale, and leverages that understanding for developing innovative non-invasive solutions in therapy and drug delivery. Our strategy is to bring concepts from different fields of applied physics such as wave physics, soft material mechanics, biomaterials, and fluid dynamics into biomedical domain for designing fundamental-driven biomedical technologies. We use variety of tools including analytical methods, computational modeling, and experiments (in vitro and in vivo) to test these technologies. Our main interest areas include developing acoustic cavitation-based treatment strategies for fibrotic diseases, including thrombosis, and cancer, and developing acoustically-controlled, physically intelligent microsystems for drug delivery.
Complete list of publications.
Mechanics of fiber networks under cavitation
Fiber networks typically made of collagen or fibrin are associated with many diseases, such as thrombosis and cancer. They impede drug delivery and regulate the cell response towards a disease phenotype. Our goal is to modulate these fibrotic networks with ultrasound-induced cavitation.
Link 1 and Link 2 for details.
Stimuli responsive physically intelligent microsystems
Here, a shape memory polymer to make a drug delivery device. The device is initially molded, loaded with drugs, and closed. Once injected into the body, it can be stimulated by ultrasound to undergo shape recovery and release drugs.
