Interdisciplinary PhD in Structural and Computational Biology and Quantitative Biosciences

Andrew R. Buller

Assistant Professor, Department of Chemistry Lab Website arbuller@wisc.edu(608) 265-8431

5112 Chemistry Shain Research Tower
1101 University Avenue
Madison, WI 53706-1322

Education

B.A./B.S., University of Iowa
Ph.D., The Johns Hopkins University
Postdoctoral, The California Institute of Technology

Protein engineering and biocatalysis

The central theme of research in the Buller lab is understanding of how to engineer new biocatalytic reactions. We believe this is the ultimate test in our understanding of enzymology. Moreover, enzymes offer a green, sustainable route to performing difficult synthetic transformations. To do this, we combine the raw power of protein directed evolution with insights gleaned from decades of detailed mechistic and bioinformatic studies. Our long-term goals are to use these new catalysts to offer unique shortcuts to synthetic routes, to probe biological systems, and to engineer pathways for the sustainable biosynthesis of natural product analogs with altered pharmacologic properties.

Andrew Buller research image

 

Photo of Andrew Buller

Areas of Expertise

  • Biophysical Chemistry
  • Biotechnology
  • Computational Biology & Bioinformatics
  • Structural Biology
  • Synthetic & Systems Biology