Jiaoyang Jiang

Pharmaceutical Sciences Division, School of Pharmacy Associate Professor Lab Website jjiang68@wisc.edu(608) 265-6732

6113 Rennebohm Hall
777 Highland Ave
Madison, WI 53705-2222


B.S., University of Science and Technology of China
Ph.D., Brown University
Postdoc, Harvard Medical School

Structure, mechanism and function of protein glycosylation in biology and disease

The overarching goal of our research program is to understand the molecular mechanisms and biological functions of protein glycosylation, especially O-GlcNAcylation. This unique modification dynamically regulates a wide variety of physiological and pathological processes. However, the mechanism underlying its dynamic regulation and aberrant function remains largely unknown. The Jiang Research Group has been active in developing innovative tools, determining novel protein structures, and uncovering regulatory pathways to characterize the functions of O-GlcNAc cycling enzymes (OGT and OGA), and design new strategies to control the level of this modification for drug discovery.

Watch a brief introduction of protein O-GlcNAcylation

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Photo of Jiaoyang Jiang

Areas of Expertise

  • Biophysical Chemistry
  • Membrane & Cellular Biophysics
  • Protein Folding Design & Function
  • Spectroscopy Microscopy Imaging
  • Structural Biology