Interdisciplinary PhD in Structural and Computational Biology and Quantitative Biosciences

Roshan Xavier Norman

Burkard Lab


B.S. Biology, Indian Institute of Science, Bangalore,India
M.S. Biology, Indian Institute of Science, Bangalore, India

Project: Spatial and functional mapping of Polo like kinase 1 (Plk1) at the centromere-kinetochore axis

Polo like kinase 1 (Plk1) is a master regulator of mitosis and is involved in maintaining chromosome segregation fidelity and structural integrity of the centromere-kinetochore architecture. I am interested in spatially mapping Plk1 and identifying its substrates and/or binding partners at the centromere-kinetochore axis (~100 nm in length). To map the distributions of Plk1 along this axis, I’m developing a modified Expansion Microscopy method which provides a resolution of ~15 nm. To identify the binding partners/substrates, I’m using a proximity based labelling approach combined with Mass Spectrometry.

ORCIDResearch Gate

Roshan Norman